Normal breast tissue harbors rare populations of aneuploid cells, displaying genetic changes often associated with invasive breast cancer—a finding that challenges the reliability of genomic profiling ...

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For adults ages 27 to 45, vaccinating against human papillomavirus (HPV) is costlier and less effective than vaccinating younger people to prevent HPV-related cancers (Ann Intern Med 2024 Nov 26 [Epub ...

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...

Treatment with eflornithine led to clinically meaningful improvements in overall survival (OS) and progression-free survival (PFS) for patients with recurrent grade 3 IDH-mutant astrocytoma, an ...

Major Finding: FastGlioma, an AI-based visual model, rapidly scores the degree of glioma infiltration in surgical samples. Concept: This approach represents a rapid, label-free surgical adjunct that ...

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Merck announced today that pembrolizumab (Keytruda) injected subcutaneously is not inferior to intravenous (IV) dosing, currently the drug’s only approved route of administration. In the phase III ...

Major Finding: A dual function supracluster was engineered to increase radiosensitivity and antitumor immunity. Concept: Gold supraclusters carrying siRNA against LGALS1 (galectin-1) reshaped the ...

1Fred Hutchinson Cancer Center, Seattle, WA.

Aging is the most important and well-recognized risk factor for cancer. Aging leads to systemic decline of physical fitness, significantly changing the macroenvironment from the early tumor initiation ...

Breast cancer is the second most common cancer globally. Most deaths from breast cancer are due to metastatic disease which often follows long periods of clinical dormancy. Understanding the ...