The Bills and 49ers play Sunday, Dec. 1 at 8:20 p.m. at Highmark Stadium in Orchard Park. The game will be broadcast on local NBC affiliates, including WHEC Channel 10 in Rochester. The game will be ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Buffalo Bills team reporter Maddy Glab joins 1st & 10 to breakdown the 49ers-Bills matchup, discuss what to expect on "SNF" ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau<a class= ...

Watch eight NFL games live on Sky Sports in Week 13, including the Kansas City Chiefs against the Las Vegas Raiders at 8pm on ...

San Francisco 49ers head coach Kyle Shanahan provided updates on his roster Wednesday ahead of the team's first full practice ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

The Buffalo Bills (9-2) are riding high these days as they head into Week 13 of the NFL season coming off a bye while also ...

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

San Francisco 49ers quarterback Brock Purdy (shoulder) has proven his value to his team on many occasions. There aren't many ...

San Francisco 49ers quarterback Brock Purdy suffered a shoulder injury back in Week 11 against the Seahawks and was held out ...