While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

Sunday could be the day Douglas has been waiting for -- because Milano is closing in on his return. The 30-year-old was a ...

Traffic and road closure information for Sunday’s Buffalo Bills game against the San Francisco 49ers has been announced by ...

Weather looks set to play a role in the Buffalo Bills' Week 13 matchup with the San Francisco 49ers.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

ORCHARD PARK, N.Y. (AP) — Gratifying as it was for Sean McDermott to catch up with his family and get some rest during ...