Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, playing 88% of the offensive snaps.

With only a few weeks left on the college football slate, NFL draft season is beginning to hit its stride. Before the San Francisco 49ers meet the Buffalo Bills in Week 13, USA TODAY’s NFL Draft Wire released their latest predictions for the 2025 draft with a new mock draft.

It seems like Trent Williams will miss his second game in a row this weekend with an ankle injury. Williams didn't practice on Wednesday. And in the

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

The Buffalo Bills are in great shape heading down the stretch of this 2024 NFL regular season. Coming out of their much-needed bye week, which, of course, was

Watch Detroit Lions running backs Jahmyr Gibbs and David Montgomery's best plays from duo's game vs. the Chicago Bears in the Week 13 matchup.

This week, Nick Bosa was asked about the 49ers' upcoming opponent, Bills quarterback Josh Allen. Here's what Bosa said. Q: What makes Josh Allen so tough to fac