The US Food and Drug Administration (FDA) has granted approval for Astellas Pharma’s azole antifungal drug Cresemba (isavuconazonium sulfate) to treat children with invasive aspergillosis (IA ...

In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.

Only four classes of antifungal drugs currently exist, and pathogen resistance to these medications complicates treatment. A ...

In the world of microbes, the evolution of resistance to antimicrobial drugs is a process that is nearly inevitable. (1) ...

An example of this is an antifungal drug class called the azoles. There is strong evidence to suggest that azole resistance in the clinic can be of environmental origin due to agriculturally used ...

Second, there is a greater chance of drug interactions. Azole antifungals (e.g., fluconazole, itraconazole and voriconazole) alter metabolism of cyclophosphamide, a cytotoxic agent, through ...

Selinexor dose optimization: A retrospective analysis. This is an ASCO Meeting Abstract from the 2024 ASCO Quality Care Symposium. This abstract does not include a full text component.

The scientists argue that because olorofim works against azole resistant infections it could save many ... Genetic mutations that cause changes in the antifungals target gene provide resistance to ...

The efficacy and safety of a combination therapy including caspofungin and another antifungal (either AMB or an azole) in a small patient group (17 patients, age range: 3–80 years) with ...