While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The National Weather Service forecast for Orchard Park calls for below-freezing temperatures in the upper 20s and a persistent 43% chance of snow through Sunday evening. Winds will be out of the west, ...

The Buffalo Bills (9-2) are riding high these days as they head into Week 13 of the NFL season coming off a bye while also ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

San Francisco 49ers head coach Kyle Shanahan provided updates on his roster Wednesday ahead of the team's first full practice ...

Buffalo Bills team reporter Maddy Glab joins 1st & 10 to breakdown the 49ers-Bills matchup, discuss what to expect on "SNF" ...

Watch eight NFL games live on Sky Sports in Week 13, including the Kansas City Chiefs against the Las Vegas Raiders at 8pm on ...

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...

Travis Hunter is No. 1 overall, but where does his teammate Shedeur Sanders go? Plus, Georgia dominates the back end of the ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau<a class= ...