San Francisco 49ers wide receiver Deebo Samuel returns the half-opening kick 60 yards into Buffalo Bills territory.

Deebo Samuel speaks to reporters after San Francisco’s 35-10 loss to the Buffalo Bills on Sunday at Highmark Stadium.Deebo ...

Missouri receiver Luther Burden III is passing on his senior season and declaring for the NFL Draft. As a result, he will not ...

Head coach Kyle Shanahan shared the latest injury and team updates emerging from the San Francisco 49ers Week 13 matchup ...

The San Francisco 49ers hosted a fan-focused event with the 49ers Pride Fan Group and PLUS (LGBTQ+) ERG to discuss being out ...

Jerry Jeudy has hit out at Steve Smith amid a resurgence in form, and Terrell Owens could be in line for a similar sort of ...

Brandon Allen is 2-8 in 10 career starts. One of them was against Josh Allen and the Bills but Brandon Allen wore No. 2 in ...

But now it is back to the drawing board, not only for McCaffrey, but the 49ers at large. His injury, of course, is just one ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

One last note of the bizarre: Niners tight end and eternal optimist George Kittle referenced a speech Shanahan gave back in ...

The San Francisco 49ers' season took a devastating turn as star running back Christian McCaffrey sustained a season-ending ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...