While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

The Buffalo Bills are set to have a classic snow game matchup against the San Francisco 49ers in Orchard Park.

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a screen pass that floated ...

Buffalo, Kansas City and Detroit have a chance to punch their playoff tickets in Week 13.The Bills (9-2) have the least ...

Every week, Thad Brown answers your questions live from Orchard Park about the Bills and their next game. This week, Buffalo ...

Buffalo Bills defensive tackle (and fashion icon) Jordan Phillips again broke out his fan-favorite winter coat during ...

The 49ers won't be signing former New York Giants quarterback Daniel Jones, but he was on their radar. Coach Kyle Shanahan ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...