Tiffany Stratton won the Women's Money in the Bank Ladder Match last year and struck gold early in 2025, becoming one of the faces of the division and riding a wave of momentum into WrestleMania 41, where she defeated Charlotte Flair in the biggest match of her career.

Cena defeated Cody Rhodes at WrestleMania 41, kickstarting his campaign to take the undisputed WWE title with him into retirement. Randy Orton struck the night after WrestleMania, renewing his two-decade feud with Cena. Orton has home-field advantage, returning to St. Louis on his quest to stop Cena.

WWE Backlash is returning with the 2025 event being held in St. Louis, Missouri. Check out the full match card, including John Cena vs. Randy Orton.