The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

The human genome is littered with scraps of millennia-old retroviruses, which hopped in, never hopped back out, and now pass from parents to children. Some of those retroviruses may wake up and ...

Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either ...

A retrovirus that inserted itself into the human genome thousands of years ago may be responsible for some cases of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou ...

Lentiviral vectors derived from primate (HIV-1, HIV-2, SIV-1) and nonprimate (FIV, EIAV, BIV) viruses are promising delivery systems for gene therapy as they transduce nondividing cells such as ...

In the most comprehensive study of its kind, researchers report that most types of retroviruses have distinct, non-identical virus structures. In the most comprehensive study of its kind, researchers ...

Scientists at the University of Texas Southwestern Medical Center and Karolinska Institutet in Sweden, found that endogenous retroviruses (ERV) also play a critical role in the body's immune defense ...

Study Soviet virus claim — Soviet claims that a virus causes amyotrophic lateral sclerosis (ALS)… are getting further study by U.S. scientists. Six of them have just returned to Bethesda, Md., to ...