The ancient biochemical 5-hydroxytryptamine—also known as 5-HT and serotonin—has been controlled through evolution to be used widely across the plant and animal kingdoms. 5-HT is used by mammals as a ...

Shanghai Institutes for Biological Sciences and Shanghaitech University have identified dopamine D2 receptor and/or 5-HT receptor agonists reported to be useful for the treatment of depression and ...

Psychedelics and Parkinson’s may trigger hallucinations through the same system, revealing how fragile the balance is between externally and internally generated perception.

Following completion of the ongoing Phase 2a proof-of-pharmacology study with BMB-101, Bright Minds plans to select and advance a 5-HT 2C molecule (BMB-105) as the dedicated compound for the PWS ...

Receptors for a specific form of serotonin is widely distributed in the bladder urothelium, investigators noted. Serotonin (5-hydroxytryptamine [5-HT]) is one of several important neurotransmitters ...

Shionogi & Co. Ltd. has synthesized spiroheterocycle derivatives acting as 5-HT2A and 5-HT2C receptor antagonists and/or inverse agonists reported to be useful for the treatment of neurodegeneration.