The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

Ricky Pearsall is facing another injury setback. He had six catches for 96 yards on Sunday, helping the San Francisco 49ers beat the Tennessee Titans 37-24.

Although nothing seems to have gone well for the 49ers this season, San Francisco still is in good shape to make a run in the 2025 NFL playoffs.

See where the San Francisco 49ers stand in Week 15 power rankings as the team comes off its bye week, riding a three-game win streak.

Brock Purdy threw a one-yard TD to George Kittle that extended the San Francisco 49ers lead to 31-10 over the Tennessee Titans.

Brandon Aiyuk hasn't played an NFL game since his serious knee injury in 2024. Here's why he won't be playing at all in 2025.

The NFL playoff race is heating up. With only a few weeks left in the regular season, the race for playoff positioning is heating up, with multiple teams fighti

The NFC West and No. 1 seed could be decided by Thursday's game between the Rams and Seahawks. Which team is favored to win?