Both teams face questions. The Packers will be missing two key defensive players due to injury — cornerback Jaire Alexander and linebacker Edgerrin Cooper. But the 49ers are hurting, too. Quarterback Brock Purdy and defensive end Nick Bosa are out. Backup Brandon Allen will replace Purdy.

Still, despite some disappointing results this season, the 49ers are loaded with talent, and given their history against Green Bay, the Packers will have to be on their A-game. For Green Bay, this will be a chance to avenge last year’s divisional-round loss to San Francisco,

In the new series, "Tom Brady's Fan Mailbag," the NFL analyst shared his favorite moments as a player at Lambeau Field.

The Green Bay Packers return to Lambeau Field to take on the San Francisco 49ers. MATT LaFLEUR…In his sixth season as the Packers' 15th head coach. Is in his 16th season in the NFL, having previously served as an offensive coordinator for two seasons (Los Angeles Rams,

Green Bay Packers are favored against a struggling San Francisco 49ers in a crucial NFC matchup at Lambeau Field, with injuries hurting the 49ers' season.