The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco 49ers.

San Francisco quarterback Brock Purdy took part in some light throwing after missing his first career game because of an injury and the 49ers are hoping he can return this week

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an injury to his throwing shoulder that has already forced him to miss a game. Purdy spent the bulk of the session of Wednesday's practice open to reporters as either a spectator or executing handoffs outside of one short pass to Jordan Mason.

The Buffalo Bills (9-2) are riding high these days as they head into Week 13 of the NFL season coming off a bye while also being able to wrap up their division early. Buffalo is definitely focused on its upcoming matchup against the San Francisco 49ers (5-6),

The Buffalo Bills may have something extra to be thankful for on Thursday. Buffalo could be a win away from a fifth straight title in the AFC East shortly after the Thanksgiving feast. The Bills can clinch the division in Week 13 if the Miami Dolphins lose to the Green Bay Packers at Lambeau Field on Thursday Night Football and Buffalo defeats the San Francisco 49ers at Highmark Stadium on Sunday Night Football.