Clinical significance of high expression of proliferating cell nuclear ...
WEBApr 17, 2020 · Although proliferating cell nuclear antigen (PCNA) plays an important role in tumor proliferation and its expression level is closely related to the biological activity of tumor cells, PCNA expression in non-small cell lung …
Clinical significance of high expression of proliferating cell nuclear ...
WEBPCNA expression in NSCLC and adjacent tissues were assessed by immunohistochemistry (IHC), western blotting, and reverse transcription polymerase chain reaction. Single factor analysis was used to study the relationship between the expression of PCNA and clinicopathological features of NSCLC.
Exploring effective biomarkers and potential immune related gene …
WEBMar 31, 2024 · Small cell lung cancer (SCLC) is well known as a highly malignant neuroendocrine tumor. Immunotherapy combined with chemotherapy has become a standard treatment for extensive SCLC.
WEBSCLC-CellMiner is an extensive cell line genomic and pharmacology resource. SCLC cell lines show a methylome consistent with their plasticity and lineage. Transcriptome analyses reveal lineage transcriptional networks and drug predictions. SCLC-Y cells differ from other subgroups by transcriptome and potential therapeutics.
SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line ...
WEBOct 10, 2020 · For instance, MYC expression is correlated with the replication processivity factor PCNA (proliferating cell nuclear antigen) in SCLC versus other tissues, including NSCLC, consistent with the replicative genotype of SCLC and high PCNA expression compared with NSCLC (Figure 2H).
Proliferating cell nuclear antigen promotes cell proliferation …
WEBAug 1, 2018 · To explore the potential mechanism of PCNA in promoting cell viability and inhibiting cell apoptosis in NSCLC, we determined the relationship of STAT3 and PCNA proteins. Results showed that both PCNA and STAT3 were co-localized in …
p53 expression in oat and non-oat small cell lung carcinomas ...
WEBAIMS--To investigate the immunohistochemical expression of p53 protein in small cell lung carcinoma (SCLC), comparing it with that in non-small cell carcinoma (NSCLC); and to evaluate the correlation between p53 and proliferating cell nuclear antigen (PCNA) expression as well as between p53 and PCNA expression and survival.
Proliferating cell nuclear antigen promotes cell proliferation …
WEBProliferating cell nuclear antigen (PCNA) functions as a bridging molecule, which targets proteins that have distinct roles in cell growth. The expression of PCNA is dysregulated in some tumors and takes part in the progression of oncogenesis.
The emerging role of Schlafen-11 (SLFN11) in predicting response …
WEBJul 1, 2024 · Small cell lung cancer (SCLC) accounts approximately 15 % of all lung cancers and is strongly associated with tobacco exposure. SCLC is a highly aggressive high-grade neuroendocrine tumor with a five-year overall survival (OS) rate of …
Small cells – big issues: biological implications and preclinical ...
WEBFeb 24, 2024 · Small cell lung cancer (SCLC) is the most aggressive histologic subtype of lung cancer and accounts for roughly 13–15% of all lung cancers [1]. The recalcitrant nature of SCLC is demonstrated by rapid disease progression accompanied with early metastatic manifestation [2].